Custom Peptide Synthesis

Custom Quote

At Peptides International, we specialize in meeting our customer’s needs and delivering the highest purity in the industry.  Hallmarks of our custom peptide synthesis services include:

  • Peptides: Simple to Complex Peptide Synthesis
  • Scale: From mg to kg Scales
  • Resins, Pre-Loaded Resins, and Protected Amino Acid Derivatives
  • Substrates by Design™

Our experienced scientists will work with you to personally ensure that your compound meets your specification.  Whether the issue is purity, quantity, or time, we will see to it that you are satisfied.  You have our word on it.

  • Multi-disulfide Peptides

Interested in mini-proteins with multiple disulfide bonds?  Peptides International researchers have extensive experience folding these highly complicated molecules to their biologically active forms, whether folding naturally or by using an orthogonal protection strategy. Examples include native molecules and analogs of conotoxins, defensins, hepcidins, chemokines, ion channel blockers (ShK, HwTX4, charybdotoxin, iberiotoxin, margatoxin, ProTx-II, mu-conotoxins, etc).  They can also customize with labels such as TAMRA, FITC or Biotin using a mini-PEG™ spacer.

  • Peptide-Protein Conjugates

Peptide-protein conjugates have a variety of applications, including the stimulation of antibodies for immunization.  These conjugates can be customized as needed, including combinations with proteins such as Albumin, Ovalbumin, and Ferritin.  Selective heterobifunctional crosslinkers allow for selective attachment of a Cys-containing peptide to the protein of your choice.  Using KLH-MCC will help streamline this reaction, and the product (KLH-6000-PI) is conveniently kept in stock at all times.

  • Peptide Derivatives

Fluorescence Resonance Energy Transfer (FRET) occurs when excitation energy is transferred from an excited fluorescent donor to a quenching acceptor in a distance-dependent manner.  Cleavage of a scissile peptide bond within a fluorescence quenched substrate leads to separation of the intramolecular donor-acceptor pair, thus allowing an increase in fluorescence. The fluorescence increase is proportional to the amount of peptide hydrolyzed.  If you need to design a substrate for a newly discovered enzyme or application, contact our specialists to begin your Substrates by Design™  project today.

  • Post Translational Modification

Fatty Acylation
Disulfide Bonds

  • Peptidomimetics

Hydroxyethylene Isostere
Reduced Peptide Bonds

  • Peptide Synthesis

Native Chemical Ligation
Dendrimeric RGD Platforms

  • Multi-step Organic Synthesis

Novel Amino Acid Derivatives
Stereo Selective Synthesis
Special Protecting Groups
Natural Product Synthesis
Chromogenic / Fluorogenic Substrates

Please contact our specialists today to begin your next custom peptide synthesis project.  We also have a full-time equivalent (FTE) services available.