Dr. Andrzej Czerwinski

Senior Peptide Chemist

Dr. Andrzej Czerwinski, Senior Peptide Chemist at New England Peptide | Peptides International, specializes in solution-phase organic and peptide synthesis. Dr. Czerwinski is generally a quiet presence. However, when he does say something, all other discussion usually stops because a well-reasoned and intel­ligent comment will follow. Andrzej’s studies and profession have taken him from his native Gdańsk, Poland to Germany, Italy, Texas, and finally to Louisville, KY. In addition to being an extremely talented peptide chemist, he is also extensively published. Professionally, he is most proud of his con­tribution to the total synthesis of the structurally and biologically unusual peptide antibiotic, edeine D,1,2 at the Technical University of Gdańsk. At Peptides International, Andrzej’s major interest has been focused on RGD peptides and click chemistry.3-12  A special place in his publication list is reserved to the work on gonorrhea vaccine candidate peptide;13 he carried out the key synthetic steps in the preparation of that peptide. Andrzej is a proud husband, father, and grandfather, who enjoys mid-to-late 20th century history, movies, and travel. We are pleased and fortunate to have such a talent!

  1. A. Czerwinski, H. Wojciechowska, R. Andruszkiewicz, J. Grzybowska, J. Gumieniak, and E. Borowski. Total Synthesis of Edeine D; J. Antibiotics, 36, 1001 (1983).
    DOI 10.7164/antibiotics.36.1001                             Open access article
  2. J. Gumieniak, R. Andruszkiewicz, A. Czerwinski, J. Grzybowska, and E. Borowski, Synthesis of the Decarboxy Analog of Edeine D; J. Antibiotics, 36, 1239 (1983).
    DOI : 10.7164/antibiotics.36.1239                           Open access article
  3. S. Ji, A. Czerwinski, Y. Zhou, G. Shao, F. Valenzuela, P. Sowinski, S. Chauhan, M. Pennington, and S. Liu, 99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging; Mol. Pharmaceutics, 10, 3304 (2013).
    DOI : 10.1021/mp400085d
  4. Y. Zheng, S. Ji, A. Czerwinski, F. Valenzuela, M. Pennington, and S. Liu, FITC-Conjugated RGD Peptides as Fluorescent Probes for Staining Integrin αvβ3/ αvβ5 in Tumor Tissues; Bioconjugate Chem., 25, 1925 (2014).
    DOI : 10.1021/bc500452y 
  5. R. Hernandez, A. Czerwinski, R. Chakravarty, S.A. Graves, Y. Yang, C. G. England, R.J. Nickles, F. Valenzuela, and W. Cai, Evaluation of Two Novel 64Cu-Labeled RGD Peptide Radiotracers for Enhanced PET Imaging of Tumor Integrin αvβ3; Eur. J. Nucl. Med. Mol. Imaging, 42, 1859 (2015).
    DOI : 10.1007/s00259-015-3085-7
  6. J. Hedhli, A. Czerwinski, M. Schuelke, A. Ploska, P. Sowinski, L. La Hood, S.B. Mamer, J.A. Cole, P. Czaplewska, M. Banach, I.T. Dobrucki, L. Kalinowski, P. Imoukhuede, and L.W. Dobrucki, Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of αvβ3 Activity; Sci Rep.; 7, 3185 (2017).
    DOI : 10.1038/s41598-017-03224-8                          Open access article
  7. J.Hedhli, S.L.L. Slania, A. Ploska, A. Czerwinski, C.J. Konopka, M. Wozniak, M. Banach, I.T. Dobrucki, L. Kalinowski, and L.W. Dobrucki, Evaluation of a Dimeric-cRGD Peptide for Targeted PET-CT Imaging of Peripheral Angiogenesis in Diabetic Mice; Sci Rep., 8, 5401 (2018).
    DOI: 10.1038/s41598-018-23372-9                           Open access article  
  8. A. Czerwinski, R. Estrada, P. Sowinski, S. Chauhan, and M.W. Pennington, Synthesis of a Novel Highly Hydrophilic Dimeric RGD Peptide, 25th American Peptide Symp., Whistler, BC, (2017).
  9. https://www.pepnet.com/PepTalk/Article/25/Click-Chemistry-Reactions-The-Latest-Developments-Regarding-Potential-Pharmaceutical-Applications 
  10. https://www.pepnet.com/PepTalk/Article/52/An-Update-On-Click-Chemistry-Reactions
  11. https://www.pepnet.com/PepTalk/Article/56/Tuning-Into-Peptide-Based-Radiopharmaceuticals-Research
  12. https://www.pepnet.com/PepTalk/Article/61/Click-Reaction-Redux
  13. S. Gulati, M.W. Pennington, A. Czerwinski, D.Carter, B. Zheng, N.A. Nowak, R.B. DeOliveira, J. Shaughnessy, G.W. Reed, S.Ram, and P.A. Rice, Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine; mBio, 10, e02552-19 (2019).
    DOI : 10.1128/mBio.02552-19                         Open access article 

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