Product Spotlight for 7/27/2020: Are You Hip To Hepcidins?

Hepcidin is a hormone that is secreted mainly by the liver. It is processed and secreted as a 25 residue peptide (hepcidin-25), although shorter variants are detected in the urine as well: hepcidin-20 (C-terminal 20 residues) and hepcidin-22 (C-terminal 22 residues).1 Truncated peptides based on the N-terminus of hepcidin have also been shown to act as agonists in mice in vivo. Hepcidin’s primary role is regulating iron homeostasis; however, it was initially discovered for its antimicrobial activity and its role in iron regulation was discovered afterwards.2 Hepcidin regulates iron by binding to ferroportin, the iron exporter, leading to its internalization and degradation. In turn, release of iron by macrophages is inhibited and iron uptake is decreased in the gut.4 The N-terminal 9 residues seem to be sufficient for stimulating ferroportin internalization and designed and improved analogs of this N-terminal fragment were active in mouse models of iron-overload disorder.3 In addition, hepcidin levels may be a useful marker of iron deficiency anemia and inflammation.4

Intriguingly, hepcidin shares sequence similarity with the SARS-CoV-2 allosteric modulation region (AMR) and also plays a role regulating interleukin 6 (IL-6), one of the players in cytokine storms, making it of possible interest in COVID-19 research. Iron is necessary for several cellular processes, and a competition for iron is likely between virus and host.5

Some of our Hepcidin products include:

  • Hepcidin / LEAP-1 (Mouse) (0.1mg vial)
    PLP-4434-s
  • FITC-labeled Hepcidin (Human)
    PLP-3793-PI

    For cell detection by flow cytometry and by fluorescent or confocal microscopy

For a complete list of our hepcidin products, click here.

References:

  1. C.H. Park, E.V. Valore, A.J. Waring, T. Ganz, Hepcidin, a urinary antimicrobial peptide synthesized in the liver., J Biol Chem, 276, 7806 (2001). Hepcidin, a urinary antimicrobial peptide synthesized in the liver.
  2. T. Ganz, E. Nemeth. Hepcidin and iron homeostasis. Biochim.Biophys.Acta, 1823(9):1434 (2012).
  3. E. Ramos, et al, Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 120, 3829 (2012). PMID 22990014 DOI: 10.1182/blood-2012-07-440743
  4. N.L. Blanchette, D.H. Manz, F. Torti, S. Torti., Expert Rev Hematol, 9 (2), 169 (2016). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849272/pdf/nihms779601.pdf
  5. W. Liu, S. Zhang, S. Nekhai, & S. Liu, Curr Clin Microbiol Rep., 7, 13 (2020).

Read more about hepcidin here.