Product Spotlight for 3/10/20: Toxins

Many of the components of  venoms and toxins are peptides. Some toxins contain the RGD-sequence (echistatin, for example), and others have a close similarity to human GLP-1 (exendin-4 is an incretin mimetic and GLP-1 agonist). As covered in several previous PepTalks, these peptides have many useful drug applications, including ion-channel blocking in pain therapeutics, antiplatelet activity, glioma cell binding, and diabetes. This week we present a handy guide of our readily available toxins, sorted by organism. New England Peptide / Peptides International carry several synthetic venoms and toxins, and their derivatives, from a variety of species. Check back periodically as the guide is a work in progress and details will continue to be added, along with new products. We can also custom synthesize a newly discovered or modified toxin to your specifications as well as create a heavy-labeled fragment for mass spectroscopy analysis.

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Bacteria Bee/Wasp      Centipede Cone Snail
Earthworm Frog Fungus Gila Monster/Lizards
Scorpion Sea Anemone Snake Spider
Various      

 

Bacteria

Catalog Number Description Species Channel Blocked Channel Type
ENT-3981-PI Enterotoxin STh Enterotoxigenic E. coli    
ENT-3744-PI Enterotoxin STp Enterotoxigenic E. coli    
STX-001 Shiga Like Toxin-1 Subunit B Recombinant Escherichia coli verotoxin    
STX-002 Shiga Like Toxin-2 Subunit B Recombinant Escherichia coli verotoxin    
PRO-373 Listeriolysin-O Recombinant, PEST free Bacteria, Listeria monocytogenes    
PRO-320 Listeriolysin-O Recombinant Bacteria, Listeria monocytogenes    
         

Bee/Wasp

Catalog Number Description Species Channel Blocked Channel Type
PAP-4257-v Apamin (0.5 mg vial) Honeybee, Apis mellifera K+ (Ca2+-Activated ) SK-type
PMS-4107 Mastoparan Wasp, Vespula lewisii    
PMS-4107-v Mastoparan (0.5 mg vial) Wasp, Vespula lewisii    
PMC-4258-v MCD-Peptide (0.5 mg vial) Honeybee, Apis mellifera K+ (Voltage-Dependent)
TOX-70001-P Melittin Honeybee, Apis mellifera    
ALR-001 Phospholipase A2 P00630 Bee Venom Protein Recombinant Honeybee, Apis mellifera    
PTK-4364-s Tertiapin (0.1mg vial) Honeybee, Apis mellifera    
TER-3833-PI Tertiapin Q Honeybee, Apis mellifera    

Centipede

Catalog Number Description Species Channel Blocked Channel Type
RHT-3832-PI RhTx Chinese red-headed centipede, Scolopendra subspinipes mutilans    

Cone Snail

Catalog Number Description Species Channel Blocked Channel Type
PCO-4265-v Conantokin G (0.5 mg vial) Marine Snail, Conus geographu    
PCO-4264-v Conantokin T (0.5 mg vial) Marine Snail, Conus tulipa    
CON-3847-PI Tau Conotoxin CnVA Cone snail, Conus consors    
PCN-4126-v α-Conotoxin GI (0.5 mg vial) Marine Snail, Conus geographu Other  
PCN-4311-v α-Conotoxin ImI (0.5 mg vial) Marine Snail, Conus imperiali    
PCN-4140-v α-Conotoxin MI (0.5 mg vial) Marine Snail, Conus magus    
PCN-4228-v α-Conotoxin SI (0.5 mg vial) Marine Snail, Conus striatus    
PCN-4217-v μ-Conotoxin GIIIB (0.5 mg vial) Marine Snail, Conus geographu Na+  
PCN-4263-v μ-Conotoxin GS (0.5 mg vial) Marine Snail, Conus geographu Na+  
PCN-4440-v μ-Conotoxin SIIIA (0.5 mg vial) Marine Snail, Conus striatus Na+  
PCN-4161-v ω-Conotoxin GVIA (0.5 mg vial) Marine Snail, Conus geographu Ca2+ N-type
PCN-4289-v ω-Conotoxin MVIIA (0.5 mg vial); ziconotide Marine Snail, Conus magus Ca2+ N-type
PCN-4283-s ω-Conotoxin MVIIC (0.1mg vial) Marine Snail, Conus magus Ca2+ P/Q-type
PCN-4283-v ω-Conotoxin MVIIC (0.5 mg vial) Marine Snail, Conus magus Ca2+ P/Q-type
PCN-4284-v ω-Conotoxin SVIB (0.5 mg vial) Marine Snail, Conus striatus Ca2+ N-type

Earthworm

Catalog Number Description Species Channel Blocked Channel Type
NLY-14802-v Lysenin Antiserum (50 μl vial) earthworm, Eisenia foetida    

Frog

Catalog Number Description Species Channel Blocked Channel Type
PBM-4086 Bombesin Frog, Bombina bombina    
PBM-4086-v Bombesin (0.5 mg vial) Frog, Bombina bombina    

Fungus

Catalog Number Description Species Channel Blocked Channel Type
PCT-4494-v Candidalysin (0.5 mg vial) Fungus, Candida albicans    

Gila Monster and Related Lizards

Catalog Number Description Species Channel Blocked Channel Type
PEX-4345-v Exendin (5-39) (0.5 mg vial) Lizard, Heloderma horridum    
PEX-3784-PI Exendin-4 Lizard, Heloderma suspectum    
HOR-269 Exendin-4 (recombinant) Lizard, Heloderma suspectum    

Scorpion

Catalog Number Description Species Channel Blocked Channel Type
PCB-4227-s Charybdotoxin (0.1mg vial) Scorpion, Leiurus quinquestri K+ (Ca2+-Activated ) IK-type
PCN-4282-v Chlorotoxin (0.5 mg vial) Scorpion, Leiurus quinquestri Other  
THS-3822-PI HsTX1 Scorpion, Heterometrus spinnifer    
PIB-3813-PI Iberiotoxin Scorpion, Buthus tamulus K+ (Ca2+-Activated ) BK-type
PIB-4235-s Iberiotoxin (0.1mg vial) Scorpion, Buthus tamulus    
PIM-4343-s Imperatoxin A (0.1mg vial) Scorpion, Pandinus imperator    
PKL-4259-s Kaliotoxin (1-37) (0.1mg vial) Scorpion, Androctonus maureta K+ (Ca2+-Activated ) BK-type
PKT-4375-s Kurtoxin (0.1mg vial) Scorpion, Parabuthus transvaa Ca2+ T-type
PAR-4290-s Margatoxin (0.1mg vial) Scorpion, Centruroides margar K+ (Voltage-Dependent)
MAR-3811-PI Martentoxin I Scorpion, Buthus martensi    
ODT-3866-PI OD1 Toxin Scorpion, Odonthobuthus doriae    
PSC-4260-s Scyllatoxin (0.1mg vial) Scorpion, Leiurus quinquestri K+ (Ca2+-Activated ) SK-type
PTT-4313-s Tityustoxin Kα (0.1mg vial) Scorpion, Tityus serrulatus K+ (Voltage-Dependent)

Sea Anemone

Catalog Number Description Species Channel Blocked Channel Type
SHK-3746-PI 5-Fam-ShK Sea Anemone, Stichodactyla helianthus K+ (Voltage-Dependent)
APE-4472-s APETx2 (0.1 mg vial) Sea Anemone, Anthopleura elegantissima Other  
PSK-4287-s Stichodactyla Toxin (0.1mg vial) Sea Anemone, Stichodactyla helianthus K+ (Voltage-Dependent)
SHK-3770-PI Stichodactyla Toxin Amide (ShK-amide) Sea Anemone, Stichodactyla helianthus    

Snake

Catalog Number Description Species Channel Blocked Channel Type
PRO-2146 Batroxobin (native) Snake, Bothrops atrox    
various Bradykinin and derivatives Pit viper, Bothrops jararaca    
PCC-4310-s Calcicludine (0.1mg vial) Green Mamba, Dendroaspis angusticeps Ca2+ L-type
PCL-4255-s Calciseptine (0.1mg vial) Black mamba, Dendroaspis polylepis Ca2+ L-type
PDN-4330-s Dendrotoxin I (0.1mg vial) Green Mamba, Dendroaspis angusticeps K+ (Voltage-Dependent)
ECT-3760-PI Echistatin Snake, Echis carinatus    
EPT-3786-PI Eptifibatide Southeastern Pygmy Rattlesnake, Sistrurus miliarius barbouri    
MAM-3778-PI Mambalgin-1 Black mamba, Dendroaspis polylepis Other  
MAM-4473-s Mambalgin-1 (0.1mg vial) Black mamba, Dendroaspis polylepis Other  
PMT-4341-s Muscarinic Toxin 1 (0.1mg vial) Green Mamba, Dendroaspis angusticeps    
PMT-4410-s Muscarinic Toxin 3 (0.1mg vial) Green Mamba, Dendroaspis angusticeps    
PMT-4340-s Muscarinic Toxin 7 (0.1mg vial) Green Mamba, Dendroaspis angusticeps    
PMT-4424-s Muscarinic Toxin α (0.1mg vial) Black mamba, Dendroaspis polylepis    
PSF-4206-s Sarafotoxin S6b (0.1mg vial) Snake, Atractaspis engaddensi    
PSF-4246-s Sarafotoxin S6c (0.1mg vial) Snake, Atractaspis engaddensi    

Spider

Catalog Number Description Species Channel Blocked Channel Type
PAG-3402-s Biotinyl-ω-Agatoxin IVA (0.1mg vial) Funnel Web Spider, Agelenopsis aperta    
GOM-3848-PI Gomesin (AgGom) South American mygalomorph spider, Acanthoscurria gomesiana    
TGX-3862-PI GpTX-1 Toxin Tarantula, Grammostola porter NaV1.7  
PCB-4393-s GsMTx-4 (0.1mg vial) Chilean Rose Tarantula, Grammostola spatulata NaV2.1  
PGX-4433-s Guangxitoxin-1E (0.1mg vial) Tarantula, Plesiophrictus guangxiensis K+ (Voltage-Dependent)
GOM-3849-PI HiGom Australian Funnel-Web Spider, Hadronyche infensa    
PCB-4455-s Huwentoxin-IV (0.1mg vial) Chinese Bird Spider, Ornithoctonus huwena Na+  
TOX-3513-PI JzTx-V Peptide ; β/κ-theraphotoxin-Cg2a Chinese earth tiger tarantula, Chilobrachys jingzhao    
PLT-3409-v L17E Cytosolic Delivery Peptide (0.5 mg vial) Carolina wolf spider, Hogna carolinensis    
PNT-4195-s Neurotoxin NSTX-3 (0.1mg vial) Papua New Guinean Spider, Nephila maculata    
PPL-4300-s PLTX-II (0.1mg vial) Spider, Plectreurys tristes Ca2+ T-type
PTX-4409-s ProTx-I (0.1mg vial) Tarantula, Thrixopelma pruriens    
PTX-3995-PI ProTx-II Tarantula, Thrixopelma pruriens Na+  
PTX-4450-s ProTx-II (0.1mg vial) Tarantula, Thrixopelma pruriens Na+  
PTX-4435-s Psalmotoxin 1 (0.1mg vial) South American Tarantula, Psalmopoeus cambridgei    
PPT-4457-s Purotoxin- 1 (0.1 mg vial) Wolf Spider, Geolycosa sp.    
PCB-4363-s SNX-482 (0.1mg vial) Tarantula, Hysterocrates giga Ca2+ Class E (R-type)
TOX-3049-PI Tarantula Venom-Derived JzTx-V Peptide Analog Chinese earth tiger tarantula, Chilobrachys jingzhao    
PAG-4294-s ω -Agatoxin TK (0.1mg vial) Funnel Web Spider, Agelenopsis aperta Ca2+ P-type
PAG-4256-s ω-Agatoxin IVA (0.1mg vial) Funnel Web Spider, Agelenopsis aperta Ca2+ P-type

Various

Catalog Number Description Species Channel Blocked Channel Type
DML-8000 δ-melusine™ - Collection I Various