Product Spotlight for 1/14/20: Boost Your Metabolism Research Capabilities

Both a new year and a new decade are upon us. A new year often comes with new resolutions, so this first Product Spotlight of 2020 will highlight a selection of peptides and related products for metabolism research, since managing weight is often a desired goal at the start of a new year. Problems with metabolism are often seen in conditions such as diabetes and obesity and are often feeding and regulatory or endocrine-related. While some conditions are lifestyle-related, others are not.  Adropin, a 76-amino acid peptide, is an energy regulator found in skeletal muscle.  A smaller fragment, Adropin 34-76, has been found to enhance intracellular signaling involved in glucose homeostasis in the liver, since the liver plays a role in insulin-mediated glucose metabolism. In addition, adropin-knockout mice were found to have insulin resistance.1 Obestatin is a metabolic hormone peptide that is produced in the stomach and other tissues.  It has 23 amino acids and is a ghrelin-associated peptide.  Ghrelin, on the other hand, plays multiple roles.  Originally thought to cause growth hormone release, it has also been found to stimulate hunger and regulate lipid and glucose metabolism. Two other peptides, the neuroendocrine regulatory peptides, NERP-1 and NERP-2, are derived from VGF and also regulate feeding behavior and play a role in energy metabolism.  Below is a small sample of products that we offer for metabolism research.  Need help finding a peptide or interested in a custom peptide synthesis?  Feel free to reach out to us.

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Products mentioned above:

For further reading and additional products, we present our previous Product Spotlights, "A Quartet of 'Controllers'", "The Orexins", and “Hunger Peptides”.

References:

  1. S. Gao, et al., The Journal of Biological Chemistry, 294, 13366 (2019).
  2. M. Tesauro et al., International Journal of Peptides, 2010 (864342), 1-7 (2010).