Mini-Product Spotlight: Zeta Inhibitory Peptide (ZIP)

ZIP (PKC-3403-v) is a Myristoylated Cell Permeable PKCζ Pseudosubstrate Inhibitor and may disrupt long-term memory1 and in a new publication, may help disrupt cocaine dependence by erasing cocaine-seeking synaptic memory.2

Synonyms/Product Alternate Names:

Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH, Myristoyl-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu

Myristoyl-PKC Zeta (113-125)

Zeta Inhibitory Peptide, ZIP

References:

  1. https://www.ncbi.nlm.nih.gov/pubmed/26354909
  2. https://www.jneurosci.org/content/early/2019/08/13/JNEUROSCI.1367-19.2019

 We recently came across a few interesting new publications on ZIP:

Reversing Cocaine-Induced Plasticity with Zeta Inhibitory Peptide

Cortical Zeta-Inhibitory Peptide Injection Reduces Local Sleep Need