Mini-Spotlight: Lugdunin

Lugdunin (LUG-3871-PI)is a “macrocyclic thiazolidine peptide antibiotic”. It is produced by the human nasal Staphylococcus lugdunensis strains and inhibits the colonization of Staphylococcus aureus. S. aureus, also known as “staph” bacteria, is often implicated in many human infections. Lugdunin may hold promise in the search for antibiotic alternatives, since current research suggests that it may be difficult for bacteria to develop a resistance to Lugdunin.1


Synonyms/Product Alternate Names:

cyclo(D-Leu-Val-D-Val-2-[1S-1-amino-2-methylpropyl]-Thiapro-D-Val-Trp)            

 

We recently came across an interesting publication on Lugdunin and analogues:

Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability

 

From our archives: New and Improved Antimicrobial Peptides!

Reference

  1. A. Zipperer, et al., Nature, 50, 511 (2016).