This Week's Product Spotlight: "Deoxyfructosyl Peptides/Amino Acids"

Reducing sugars such as glucose are known to glycate proteins by non-enzymatic reaction with amino groups of proteins in vivo. The series of reactions is known as the Maillard reaction starting from Amadori rearrangement, and the modified compounds are called Amadori compounds and/or Maillard compounds. After oxidation and dehydration reaction, it leads to AGEs (Advanced Glycation End Products). AGEs typified by Pentosidine have been reported to affect age-related diseases.
 https://www.pepnet.com/res/uploads/media//Amadori-rearrangement-reaction-of-D-glucose-with-N-terminal-Val-residue-of-hemoglobin-in-vivo.png

Figure 1. Amadori rearrangement reaction of D-glucose with N-terminal Val residue of hemoglobin in vivo.

  
Glycated hemoglobin A1c (HbA1c) is an Amadori compound in which blood glucose is bound to the N-terminal Val residue of hemoglobin β chain. HbA1c is used as a diagnostic marker for diabetes, and its amount can be measured by the enzymatic method, as shown in Figure 2.

https://www.pepnet.com/res/uploads/media/Measurement-of-HbA1c-by-enzymatic-method-revised.png

Figure 2. Measurement of HbA1c by enzymatic method.


We have released several deoxyfructosyl products in small package sizes.

Code

Product

Quantity

Price

CAR-24011-v

1-Deoxyfructosyl-Gly

1 mg vial

 

CAR-24012-v

Lys(1-Deoxyfructosyl)

1 mg vial

 

CAR-24013-v

1-Deoxyfructosyl-Val [Fru-Val]

1 mg vial

 

CAR-24014-v

1-Deoxyfructosyl-Val-His [Fru-Val-His]

1 mg vial

 

CAR-24015-v

1-Deoxyfructosyl-Val-His-Leu-Thr-Pro-Glu

1 mg vial

 

Bulk quantities, as well as custom synthesis of different glycosylation reaction products such as 3-Deoxyglucosone (3-DG) / Carboxymethyl Lysine (CML), and AGEs, are available on request. Please feel free to contact us.

References

  1. U. Kobold, J.O. Jeppsson, T. Duelffer, A. Finke, W. Hoelzel, and K. Miedema, Clin. Chem., 43, 1944 (1997).
  2. T. Nakanishi and A. Shimizu, J. Chromatogr. B, 746, 83 (2000).
  3. K. Hirokawa, K. Gomi, and N. Kajiyama, Biochem. Biophys. Res. Commun., 311, 104 (2003).