Mini-Spotlight: Fmoc-MeDbz

Fmoc-MeDbz (FMD-2331) is a useful linker in peptide synthesis, and, in particular, in preparing key C-terminal peptide thioester intermediates in native chemical ligation (NCL). The MeDbz group is also less prone to acetylation during sold-phase peptide synthesis (SPPS) than the first generation Nbz linker.

Synonym: 3-[(9-Flurenylmethyloxycarbonyl)Amino]-4-(Methylamino)Benzoic Acid

CAS Number: 1788861-35-7

Reference:

  1. J.B. B-Canosa, B. Nardone, F. Albericio, & P.E. Dawson, J. Am. Chem. Soc., 137, 7197 (2015).

Additional reading: Exploiting the MeDbz Linker to Generate Protected or Unprotected C‐Terminally Modified Peptides