This Week's Product Spotlight: "A Family of Natural Born Killers"

A family of serine proteases known as Granzymes are found in the lytic granules of cytotoxic T lymphocytes and natural killer (NK) cells. Both are involved in the killing of susceptible target cells1, which include virally infected cells and tumor cells,2 making them of interest in treating cancer and infections.

There are different types of granzymes that have been identified since their discovery by Jürg Tschopp's group,3,4 including Granzyme A, B, H, K, and M.

Peptides International is pleased to offer two new items, one an inhibitor of, and the other a substrate of Granzyme M.  We also have numerous other granzyme- and apoptosis-related products, with just a sampling listed below.

Ac-Lys-Val-Pro-Leu-ACC
SGM-3240-v
(M.W. 697.8) C35H51N7O8
Selective Fluorogenic Substrate for Granzyme M

Ac-Lys-Val-Pro-Leu-CH2Cl
IGM-3241-v
(M.W. 530.10) C25H441N5Cl    [1176290-36-0]
Selective Inhibitor for Granzyme M

Other Related Products

Granzyme-K Human Recombinant
ENZ-741

Non-Metastatic Cells 1 Human Recombinant
PRO-715

Ac-Ile-Glu-Thr-Asp-MCA [Ac-IETD-MCA]
MCA-3195-v
(M.W. 675.68) C31H41N5O12      [348079-17-4]

Ac-Ile-Glu-Thr-Asp-H (Aldehyde)
ICA-3196-v
(M.W. 502.52) C21H34N4O10     [191338-86-0]
Inhibitor for Caspase-8/6 and Granzyme B (Deduced from the Cleavage Site of Procaspase-3)

 

https://www.pepnet.com/res/uploads/media//Mechanisms_of_suppression_by_regulatory_T_cells.png

Gwilz [CC BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0)]

Please click through each link for details of the specific products, and should you want a custom peptide synthesis variant of these or any other items, please contact us for a quote.

References:

  1. https://link.springer.com/article/10.1007/s00251-018-1062-6
  2. https://www.ncbi.nlm.nih.gov/pubmed/14685782?dopt=Abstract
  3. https://www.ncbi.nlm.nih.gov/pubmed/3555842
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252830/

https://www.pepnet.com/res/uploads/media//Antibody-dependent_cell-mediated_cytotoxicity.png

Simon Caulton [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)]

Related References of Interest:

L. Wu, L. Wang, G. Hua, K. Liu, X. Yang, Y. Zhai, M. Bartlam, F. Sun, and Z. Fan, J. Immunol., 183, 421 (2009). (Original)
S. Mahrus, W. Kisiel, and C.S. Craik, J. Biol. Chem., 279, 54275 (2004). (Original)
S. Mahrus and C.S. Craik, Chem. Biol., 12, 567 (2005).