This Week's Product Spotlight: "HA Peptide- No Laughing Matter for Researchers"

The hemagglutinin (HA) protein, a surface glycoprotein, is responsible for binding the influenza virus to sialic acid receptors, initiating infection. The HA Peptide corresponds to amino acids 98-106 of the HA protein and is the hemagglutinin epitope, a general epitope tag in expression vectors.  This tag can be used to outcompete anti-HA antibody binding to HA-tagged fusion proteins in immunoassays since it is easily recognized by hemagglutinin antibodies.1

One encouraging strategy is to combat influenza viruses by inactivating the fusion process between the viral and host membranes.2

Additionally, there was a publication that reported an αβ T‐cell receptor (αβTCR)/hemagglutinin (HA) peptide/human leukocyte antigen (HLA)‐DR1 complex was secured by connecting HA peptide with human HA1.7 αβTCR, to increase the local concentration of the interacting proteins once the peptide has been loaded onto the major histocompatibility complex (MHC) molecule.3

HA Peptide is also been used for cosmeceutical applications.4

HA Peptide
HAP-70000-PI
(M.W. 1102.18) C53H67N9O17    [92000-76-5]

Please click through the link for details of this product, and should you want a custom peptide synthesis variant of the HA Peptide or any other, please contact us for a quote.

References:

  1. K. Sekikawa & C.-J. Lai, Proc.Nat.Acad.Sci., 80, 3563 (1983).
  2. D. Lousa, et al., Free Radical Biology and Medicine, 120 (1), S125 (2018).
  3. J. Hennecke, et al., The EMBO Journal, 19, 5611 (2000).
  4. R. Teschke, Int. J. Mol. Sci., 20(1), 211 (2019).