This Week's Product Spotlight: "Spiders Do It: Gomesin and Melanoma"

Gomesins are antimicrobial peptides that were first derived from spider venoms. AgGom was initially isolated from the tarantula, Acanthoscurria gomesiana, and its analog, HiGom, was then isolated from the Australian funnel-web spider, Hadronyche infensa. Both have 18 amino acids, differing by only two (in bold, below), and have proven anticancer activity. A recent study demonstrated that they induce apoptosis in melanoma cells.1 Given these results, gomesin analogs have potential in melanoma-targeting therapies.

https://www.pepnet.com/res/uploads/media/A-Spider-Jan-Vincentsz-van-der-Vinne-Dutch-Haarlem-1663-1721-Haarlem-.jpeg

As experts in the synthesis of venom and toxin compounds, we are pleased to introduce two new gomesin analogs, AgGom and HiGom:

AgGom
GOM-3848-PI
Pyr-Cys-Arg-Arg-Leu-Cys-Tyr-Lys-Gln-Arg-Cys-Val-Thr-Tyr-Cys-Arg-Gly-Arg-NH2
Disulfide Bonds: Cys2-Cys15 and Cys6-Cys11

HiGom
GOM-3849-PI
Pyr-Cys-Arg-Arg-Leu-Cys-Tyr-Arg-Asn-Arg-Cys-Val-Thr-Tyr-Cys-Arg-Gly-Arg-NH2
Disulfide Bonds: Cys2-Cys15 and Cys6-Cys11

We invite you to take a look at our other toxins here. If you are interested in a custom toxin, or any other product or service, please contact us here.  See what the bees are busy doing too, in this week's PepTalk.

 Reference:

1. M.P. Ikonomopoulou, et al., Scientific Reports, 8, 11519 (2018).