The Renin-Angiotensin System (RAS) is responsible for controlling blood pressure, sodium balance, and body fluid homeostasis. Angiotensin is a substrate of renin that cleaves a 10-residue peptide from the N-terminus, producing Angiotensin I, which is subsequently cleaved by the angiotensin converting enzyme (ACE) to form Angiotensin II. Angiotensin II is an 8-residue peptide and the most active product of the RAS system. It binds to specific receptors and triggers a range of events that impact nearly every body system. ACE inhibitors, which disrupt the formation of Angiotensin II, have been used successfully for the treatment of kidney diseases, congestive heart failure, and hypertension. Meanwhile, Bradykinin is an important biologically active peptide substrate for ACE. Bradykinin plays a role in lowering blood pressure and may also play a protective role in kidney function in diabetics. 1
Bradykinin (Human, Bovine, Rat, Mouse)
0.5 mg net vial PBK-4002-v
- M.A. Sparks et al., Compr Physiol., 4(3), 1201 (2014).
Read more about Bradykinin here, including its role in inflammation and apoptosis in Parkinson’s Disease.