This Week's Product Spotlight: For RAS, It's No Pressure

The Renin-Angiotensin System (RAS) is responsible for controlling blood pressure, sodium balance, and body fluid homeostasis. Angiotensin is a substrate of renin that cleaves a 10-residue peptide from the N-terminus, producing Angiotensin I, which is subsequently cleaved by the angiotensin converting enzyme (ACE) to form Angiotensin II. Angiotensin II is an 8-residue peptide and the most active product of the RAS system. It binds to specific receptors and triggers a range of events that impact nearly every body system. ACE inhibitors, which disrupt the formation of Angiotensin II, have been used successfully for the treatment of kidney diseases, congestive heart failure, and hypertension. Meanwhile, Bradykinin is an important biologically active peptide substrate for ACE. Bradykinin plays a role in lowering blood pressure and may also play a protective role in kidney function in diabetics. 1
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Angiotensin I (Human)
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
0.5mg net vial  PAN-4007-v
25mg PAN-4007

Angiotensin II (Human)
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
0.5mg net vial PAN-4001-v
25mg PAN-4001

Angiotensin (Human, 1-7)
Asp-Arg-Val-Tyr-Ile-His-Pro
0.5mg net vial PAN-4332-v
25mg PAN-4332

Click here for more Angiotensin peptides.

Bradykinin (Human, Bovine, Rat, Mouse)
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
0.5 mg net vial PBK-4002-v

Click here for more Bradykinin fragments.

Click here for products related to Renin, including substrates and inhibitors.

Reference:

  1. M.A. Sparks et al., Compr Physiol., 4(3), 1201 (2014).

Read more about Bradykinin here, including its role in inflammation and apoptosis in Parkinson’s Disease.