This Week in the Product Spotlight: "LH-RH and other Neurohormones for Cancer Research"

Luteinizing hormone-releasing hormone (LH-RH), or gonadotropin-releasing hormone (GnRH), is secreted by the hypothalamus and triggers the pituitary gland to release the hormones, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) that make estrogen and progesterone in females and testosterone in males. Since some cancers require or respond to estrogen or testosterone in order to grow, agonists of LHRH are often used as treatment.1 Growth hormone releasing factor (GRF or GHRH) is important in many cellular processes and in sleep promotion. It was first isolated from a pancreatic tumor.1 And lastly, Human Chorionic Gonadotropin (hCG) is released during pregnancy, however, research has found that some tumors express it, making it a useful tumor marker.3,4 When circulated during pregnancy, it has also been found to provide long-term protective effects against breast cancer.5 The following are some of the neurohormones that Peptides International carries for cancer research, and are also included in the current sale.

LH-RH (Human)
PLR-4013 (25mg, 100mg), PLR-4013-v (0.5mg vial), HOR-261

LHRH Protein
HOR-268

Anti LH-RH (Human, Rat) Serum (50 ul)
NAY-86010-v

Anti Pro-LH-RH (1-26) (Human) Serum (50 ul)
NAY-8310-v

Antide Acetate
GnRH/LHRH antagonist
HOR-242

Buserelin
HOR-255

Goserelin
GnRH/LH-RH super-agonist
HOR-256

GRF
PGR-4127-s (0.1mg vial), PGR-4127-v (0.5mg vial)

Histrelin
HOR-244

Leuprolide Human
GnRH/LH-RH agonist
HOR-260

Octreotide
PCI-3738-PI

Somatostatin-28
SRIF(Somatotropin Release Inhibiting Factor)/GIF(Growth Hormone Release Inhibiting Factor)
PSI-3747-PI

Somatostatin
PSI-4023 (25mg), PSI-4023-v (0.5mg vial), HOR-299

Triptorelin Acetate
GnRH/LH-RH agonist
HOR-238

Kisspeptin-10 (Human)
Stimulator of LH-HR/GnRH and gonadotropin secretion
PKS-4389-v

Kisspeptin-10 (Rat)
PKS-4453-v

Chorionic Gonadotropin Human (hCG)
HOR-250

Chorionic Gonadotropin Beta Human Recombinant
HOR-007

References:

  1. https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=luteinizing
  2. http://science.sciencemag.org/content/218/4572/585
  3. https://www.ncbi.nlm.nih.gov/pubmed/22331727
  4. https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis/tumor-markers-fact-sheet
  5. http://cancerres.aacrjournals.org/content/canres/early/2016/10/26/0008-5472.CAN-16-1524.full.pdf