This Week in the Product Spotlight: "The Matrix Reloaded: Revolutions in Research"

Probing the Matrix

As featured in our current sale and PepTalk, the Matrix Metalloproteinases (MMPs) are zinc-dependent endoproteinases.1 MMPs are involved in the degradation of the extracellular matrix (ECM) and are thought to provide a pathway for invasion by cancerous tumor cells. Peptides International carries both the MMP substrates and inhibitors as well as the proteinases themselves.

The TAPI (TNF-Alpha Protease Inhibitor) analogs have been shown to block TNF-α processing and also to inhibit L-selectin action by inhibiting the formation of a key precursor protein. They are inhibitors for Collagenase, MMP, and α-Tumor Necrosis Factor.

MMP substrates, on the other hand, are used in spectrophotometric assays of many matrix metalloproteinases. The table below is a useful cross-reference the MMP substrates that are carried by Peptides International.

For a complete list of MMP products, click here to view them on the Peptides International website. Specific substrates and inhibitors can also be synthesized by design to meet your research needs. Contact us today if you need help locating an item, procuring a bulk quotation, or designing a custom peptide.

References:

  1. P. Van Lint & C. Libert, J Leukoc Biol., 82(6), 1375 (2007).
  2. L. Sun et al., Biomater. Sci., (2018). Advance Article

The entire archive of Peptides International Product Spotlights is available here.  The topics range from some of the most popular items we have available to those lesser known ones that still have compelling research applications.  They often are chosen due to recently published articles that feature them.  They are permanently posted here, so read at your leisure!