This week in the Product Spotlight!

New Amyloid β-Protein Products

Peptides International is pleased to introduce some new Amyloid β-Protein peptide fragments. In Alzheimer’s Disease, plaques are thought to be formed primarily by fragments 1-40 and 1-42 of Amyloid β-Protein. However, the truncated version, 11-40, is also found in abundance in cerebrospinal fluid. This fragment is thought to have a higher binding affinity to Cu2+.1 Both truncated forms, Amyloid β-Protein (11-40) and [Pyr11]-Amyloid β-Protein (11-40), are found in Alzheimer’s Disease and Down’s Syndrome brains.2

Amyloid β-Protein (11-40) (Human)
PAB-4492-v

[Pyr11]-Amyloid β-Protein (11-40) (Human)
PAB-4493-v

Meanwhile, 26-O-acyl isoAβ1-42 is a water-soluble isopeptide that can be used to prepare Amyloid β-Protein (1-42) through a pH-induced acyl shift. By dissolving in water, an O->N migration occurs, generating native Aβ1-42 through an intramolecular acyl migration. The inclusion of the iso-depsi-peptide bond disrupts aggregation, alleviating a common difficulty when working with Amyloid β-Protein (1-42).3

Amyloid β-Protein (1-42, O-acyl isopeptide)
PAB-AF683

Our complete Amyloid β-Protein product line can be found here. We can also prepare custom Amyloid β-Protein fragments. Contact one of our peptide specialists today for a quotation.

References:

  1. J.D. Barritt & J.H. Viles, J. Biol. Chem., 290, 27791 (2015). (Pharmacol.)
  2. K. Liu, et al., Acta Neuropathol., 112, 163 (2006). (Pharmacol.)
  3. T. Yoshiya, et al., Bioorg. Med. Chem. Lett., 24, 3861 (2014).

The entire archive of Peptides International Product Spotlights are available here.  The topics range from some of the most popular items we have available to those lesser known ones that still have compelling research applications.  They often are chosen due to recently published articles that feature them.  They are permanently posted here, so read at your leisure!

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