Peptides International is pleased to introduce some new Amyloid β-Protein peptide fragments. In Alzheimer’s Disease, plaques are thought to be formed primarily by fragments 1-40 and 1-42 of Amyloid β-Protein. However, the truncated version, 11-40, is also found in abundance in cerebrospinal fluid. This fragment is thought to have a higher binding affinity to Cu2+.1 Both truncated forms, Amyloid β-Protein (11-40) and [Pyr11]-Amyloid β-Protein (11-40), are found in Alzheimer’s Disease and Down’s Syndrome brains.2
Amyloid β-Protein (11-40) (Human)
[Pyr11]-Amyloid β-Protein (11-40) (Human)
Meanwhile, 26-O-acyl isoAβ1-42 is a water-soluble isopeptide that can be used to prepare Amyloid β-Protein (1-42) through a pH-induced acyl shift. By dissolving in water, an O->N migration occurs, generating native Aβ1-42 through an intramolecular acyl migration. The inclusion of the iso-depsi-peptide bond disrupts aggregation, alleviating a common difficulty when working with Amyloid β-Protein (1-42).3
Amyloid β-Protein (1-42, O-acyl isopeptide)
- J.D. Barritt & J.H. Viles, J. Biol. Chem., 290, 27791 (2015). (Pharmacol.)
- K. Liu, et al., Acta Neuropathol., 112, 163 (2006). (Pharmacol.)
- T. Yoshiya, et al., Bioorg. Med. Chem. Lett., 24, 3861 (2014).
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