This Week in the Product Spotlight: Alpha-2-Gliadin (57-89)

Celiac disease is a condition that occurs when the upper intestinal tract becomes inflamed, resulting in poor absorption of nutrients, and is thought to be triggered by the consumption of gluten proteins.2 Gluten is the main wheat flour protein, and is comprised mainly of gliadin and glutenin. Several regions of the N-terminal end of gliadin are immunologically active. A proline in the sequence makes hydrolysis sluggish, due its cyclical nature and secondary amine.1 A 33-residue peptide, derived from α2-gliadin (Alpha-2-Gliadin (57-89)),has been found to be resistant to enzymatic cleavage by intestinal peptidases, yet is highly immunoreactive, due to three overlapping T-cell epitopes.2 The high immunoreactivity of α2-Gliadin (57-89) makes it important in the study of celiac disease.

Peptides International is pleased to offer the following new product:

α-2-Gliadin (57-89)
H-LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF-OH
GIL-3994-PI

We also carry:
Gliadin Wheat Recombinant
PRO-114

Do you need another fragment of gliadin, a labeled version, or something entirely different? As a leader in custom peptide synthesis, we can also custom prepare a peptide or related product to suit your research needs. Contact one of our specialists today!

References:

  1. C.L. Gerez, et al., Letters in Applied Microbiology, 47, 427 (2008). doi:10.1111/j.1472-765X.2008.02448.x
  2. K. Schalk, et al., Scientific Reports, 7 (45092), (2017).

 

The entire archive of Peptides International Product Spotlights are available here.  The topics range from some of the most popular items we have available to those lesser known ones that still have compelling research applications.  They often are chosen due to recently published articles that feature them.  They are permanently posted here, so read at your leisure!

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