Feeding Regulatory Peptides
Energy balance plays an important role in regulating weight, and loss of balance can contribute to obesity and other eating disorders. Melanin-concentrating hormone (MCH), an orexigenic signal that increases food intake, and melanocortin or melanocyte-stimulating hormone (MSH), an anorexigenic signal that decreases food intake, are participants in this balancing act. Therefore, much effort has been focused on developing MCH and MSH agonists and antagonists as research tools and potential therapy for eating disorders. Peptides International now offers both a selective agonist Ac-D-Arg-[Cys-Met-Leu-Asn-Arg-Val-Tyr- Arg-Pro-Cys]-NH2 (PMC-3886-PI)1 and antagonist Ac-Arg- [Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys]-NH2 (PMC-3881-PI)2 for the MCH-1 receptor.
For those interested in studying anorexigenic signaling, Peptides International offers 3 melanocortin receptor agonists, Ac-Nle-cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH2 (PMC-3683-PI), [Nle4, D-Phe7]-α-MSH-Amide (PMC-3669-PI), and Ac-Tyr-Val-Nle-Gly-His-D-Phe-Arg-Trp-Asp-Arg-Phe- Gly-NH2 (PMC-3685-PI). The former, also known as melanotan II, is a popular choice due to its stability and ability to cross the blood-brain barrier and has been shown to inhibit food intake in mice. In addition, a selective melanocortin receptor 4 antagonist (PMC-3887-PI)8 is available and should prove useful for understanding the physiological role of the melanocortin receptor system in energy homeostasis and related diseases.