A Systems Pharmacology-Based Approach to Identify Novel Kv1.3 Channel-Dependent Mechanisms in Microglial Activation
Srikant Rangaraju, Syed Ali Raza, Andrea Pennati, Qiudong Deng, Eric B. Dammer, Duc Duong, Michael W. Pennington, Malu G. Tansey, James J. Lah, Ranjita Betarbet, Nicholas T. Seyfried & Allan I. Levey
Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the molecular and cellular mechanisms regulated by Kv1.3 channels are poorly defined.
A Unique Peptide with Optimal Nav1.7 Properties for Pain ManagementA look at a just-published open access article, coauthored by this blog post writer.
A Database of Potassium Channel Toxins from Scorpion VenomA resource for researchers of potassium channel blocking toxins
Nav-igating the ChannelsA navigational map to the voltage-gated sodium channels (VGSCor Navs), their sub-types and some of the toxins that block them, including Peptides International's latest release, GpTX-1.