A Systems Pharmacology-Based Approach to Identify Novel Kv1.3 Channel-Dependent Mechanisms in Microglial Activation



Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the molecular and cellular mechanisms regulated by Kv1.3 channels are poorly defined.

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