Peptide therapeutics from venom: current status and potential

The number of venom-derived peptides that have successfully progressed to the clinic is currently limited, the prospects for venom-derived peptides look very optimistic.

A Systems Pharmacology-Based Approach to Identify Novel Kv1.3 Channel-Dependent Mechanisms in Microglial Activation

J Neuroinflammation. 2017 Jun 26;14(1):128. doi: 10.1186/s12974-017-0906-6

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

Mar Drugs. 2015 Jan 16;13(1):529-42. doi: 10.3390/md13010529.

Distribution and Kinetics of the Kv1.3-Blocking Peptide HsTX1[R14A] in Experimental Rats

Sci Rep., 7, Article number: 3756 (2017).

Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of αVβ3 Integrin Activity

Sci Rep., 7, 3185 (2017).

Reinvestigation of the biological activity of D-allo-ShK protein.

J Biol Chem. 2017 Jun 8. pii: jbc.M117.793943. doi: 10.1074/jbc.M117.793943. [Epub ahead of print]

KCa1.1 channels regulate β1 integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes

FASEB J. 2017 Apr 20. pii: fj.201601097R. doi: 10.1096/fj.201601097R. [Epub ahead of print]

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability and Engineering

Biochemistry. 2017 Apr 24. doi: 10.1021/acs.biochem.7b00120. [Epub ahead of print]

Prolonged Immunomodulation in Inflammatory Arthritis Using the Selective Kv1.3 Channel Blocker HsTX1[R14A] and Its PEGylated Analog

Clin Immunol. 2017 Apr 4. pii: S1521-6616(16)30620-9. doi: 10.1016/j.clim.2017.03.014. [Epub ahead of print]

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

Scientific Reports 7, Article number: 39662 (2017) (Open Access)