Calpain, a calcium-activated cysteine protease present in most mammalian tissues, is a potential therapeutic target for neurodegeneration prevention. Calpain has been implicated in neural cell death associated with cerebral ischemia, neurodegenerative processes such as Alzheimer’s disease, myocardial ischemia, and cataract formation.
Ac-Leu-Leu-Nle-H and Ac-Leu- Leu-Met-H aldehydes are non-specific cysteinyl protease inhibitors.2 These cell-permeable aldehydes are most effective against the chymotrypsin-like proteolytic activity of the proteasomes. Both ALLN and ALLM should be useful for calpain function studies since this remains poorly understood. Here is a list of calpain inhibitors.