Mitosis and the Mesh

While using electron microscopy for studying the process of mitosis about 40 years ago, researchers were gaining insight involvement of the mitotic spindle and its function in separating the chromosomes into the two daughter cells during cell division. The mitotic spindle is a cellular structure made of microtubules that bundle together in groups of 20-40 fibers to form the kinetochore fibers (K-fibers). These researchers discovered that there was electron density present between microtubules in the K-fibers.  With improving technology, this electron density amongst these bundles were better resolved and subsequently found to be irregularly shaped 5-nm thick bridges stretching from 6-20 nm to connect 2 microtubules.  Enter Stephen Royle, a researcher at the University of Warwick in Coventry, UK, and his team, who regularly used 2-D electron microscopy to study mitosis.   In 2006, they wanted to see what these bridges looked like in three dimensions.  This led them to discover a new cellular structure, "the mesh" which is composed of clathrin and transforming acidic coiled-coil containing protein 3.  Think of springs connected by non-uniform strands.  The mesh is composed of these strands.    They also investigated how "...changes in mesh composition result in mitotic problems."

 

The in-depth article and related reference information regarding Dr. Boyle and his team’s work can be found at http://www.biotechniques.com/news/The-Mesh-A-Newly-Discovered-Cellular-Structure/biotechniques-359682.html#.V7RmgK6bTIb

 

Thanks to George Schroeder, MD for alerting me to this article.

 

For a Peptides International offering related to this posting, see TUBB3 (Human) andTUBB3 Antibody.

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Recombinant Proteins

Robert Brousseau

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Robert Brousseau, the Director of Marketing and Catalog Sales Development at Peptides International, has a wide range of responsibilities that include maintaining the Peptides International brand integrity and creating and implementing all materials related to marketing the company's product line. He is also tasked with the catalog portfolio sales.  Since joining the company in 2004, he has incorporated media that now includes printed material such as product brochures and the long-running PEPNET newsletter, along with the company Website, social media, email and other outlets.  Additionally, he assists the staff with IT issues they encounter.  Bob has a background in graphic design, marketing, and advertising, in addition to project management and packaging.  He received his B.A. in Art from the University of Louisville, with additional post-graduate studies in education and design.