OD1 Toxin

by Michael Pennington

OD1 Toxin is a scorpion peptide that was originally isolated from the venom of the scorpion Odonthobuthus doriae.1  OD1 is a 65 residue peptide stabilized by 4 intramolecular disulfide bonds.2  OD1 potently inhibits fast inactivation of mammalian channels Nav1.7 (EC50 4.5 nM), Nav1.4 (EC50 10 ± 2 nM) and Nav1.6 (EC50 47 ± 10 nM).1  OD1 also blocks fast inactivation of the para/tipE insect channel (EC50 80 nM). OD1 weakly affects mammalian Nav1.3 and Nav1.5 (EC50 > 1 μM) and does not affect Nav1.2 and Nav1.8. OD1 induces spontaneous pain when injected in animal in association with or without veratridine and can be used to test the analgesic effects of Nav1.7 blockers in-vivo.3  We are pleased to offer our first α-type scorpion Nav channel toxin for your research needs.

Sequence: H-Gly-Val-Arg-Asp-Ala-Tyr-Ile-Ala-Asp-Asp-Lys-Asn-Cys-Val-Tyr-Thr-Cys-Ala-Ser-Asn-Gly-Tyr-Cys-Asn-Thr-Glu-Cys-Thr-Lys-Asn-Gly-Ala-Glu-Ser-Gly-Tyr-Cys-Gln-Trp-Ile-Gly-Arg-Tyr-Gly-Asn-Ala-Cys-Trp-Cys-Ile-Lys-Leu-Pro-Asp-Glu-Val-Pro-Ile-Arg-Ile-Pro-Gly-Lys-Cys-Arg-NH2 

Disulfide Bonds: C13-C64 ; C17-C37 ; C23-C47 ; C27-C49

  1. A. Jalali, et al., OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS,579, 4181 (2005). PMID: 16038905
  2. T. Durek, et al., Chemical Engineering and Structural and Pharmacological Characterization of the α‑Scorpion Toxin OD1. Chem. Biol., 8, 1215 (2013). PIMD: 3527544
  3. Maertens, et al., Potent Modulation of the Voltage-Gated Sodium Channel Nav1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae. Mol. Pharmacol., 70(1), 405 (2006). PMID: 16641312

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