A ∩ of 2C3*

*A Union of Two Catalog Core Competencies (With apologies to mathematical accuracy for the sake of literary license).https://www.pepnet.com/res/uploads/media//Intersection-of-RGDs-and-Peptide-Venoms.png

Typically, we cover either venoms or RGD peptides in our PepTalk, but in this case we are looking at a unique intersectional space for them. Viper venoms contain several components, many of which are proteins or peptides.  One such group is the disintegrins.  Disintegrins are disulfide-rich and prevent fibrinogen bonding and subsequent platelet aggregation by binding to the αIIbβ3 receptor.1 They contain the Arg-Gly-Asp (RGD) or Lys-Gly-Asp (KGD) sequence, which is of importance for binding to the RGD-integrins.  This sequence is a cell attachment site for many proteins and are involved in many cell processes, including cell proliferation and differentiation.2 

In a new paper, published in Toxins, scientists look at the potential for snake venom disintegrins as an antithrombotic treatment. Thrombosis is the formation of blood clots within a blood vessel. This process can be dangerous with a need to prevent thrombosis, leading to favorable cardiovascular outcomes. 

https://www.pepnet.com/res/uploads/media//cover-toxins-v11-i7.jpg

However, traditional antithrombotics can cause dangerous extraneous bleeding. Kuo et al., report that integrin conformational changes seem to be the cause.  They looked at new RGD peptides derived from snake venom that do not cause these conformational changes and, therefore, do not increase bleeding risk.3 This new approach may lead to the development of safer and equally effective antithrombosis treatments. 

References:

1. M. Pennington, et al., Bioorganic & Medicinal Chemistry, 26(10), 2738 (2018).

2. https://www.pepnet.com/about-peptides-international/News/Article/313/This-week-s-Product-Spotlight-The-RGD-Peptides   

3. Yu-Ju Kuo, Ching-Hu Chung, & Tur-Fu Huang, Toxins, 11(7), 372 (2019). 

Industry News , Biologically Active Peptides

Denise Karounos

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Denise Karounos joined Peptides International in October 2016. After completing her BS in chemistry from West Virginia University, she spent time as an organic chemist at Bachem Bioscience synthesizing peptides and amino acid derivatives. Denise has experience with both solid and solution-phase peptide synthesis, and has worked under both research and cGMP settings. After completing her MBA from Saint Joseph’s University, Denise transitioned into product management of peptides and amino acid derivatives. In her marketing role, she had many duties including but not limited to product management, market research, creating and producing marketing materials, handling US catalog distribution and customer database, email marketing, quoting and inside sales, sales calls, and coordinating and attending trade conferences. 

At PI, Denise's duties encompass both sales and marketing, bringing to bear her extensive lab and sales support experience. Contact her today and see how Denise can assist you with your peptide research project.