Yet Another Function for Neuromedins?
The Neuromedins are a diverse family of neuropeptides and are G protein-coupled receptor (GPCR) ligands. They control a variety of functions such as vasoconstriction, hormonal regulation, smooth muscle contraction, feeding regulation, nociceptive pain, stress regulation, and play a possible role in tumor suppression.
In our related Product Spotlight from the PEPNET newsletter, Vol. 31 issue 4, we showcased three recently released Neuromedin items. By happenstance, there is also a new paper that highlights an aspect of the feeding-regulation characteristics found in this class of peptides in conjunction with the most common eating disorder. In the journal Nutrients, authors from the Hommel laboratory within the Center for Addiction Research which is affiliated with the University of Texas, correlated binge-type eating in rats with synaptosomal NMUR2 (G protein-coupled receptor Neuromedin U Receptor 2) protein expression in the NAc (nucleus accumbens) and the VTA (ventral tegmental area) of rats.
Depending on the ratio of fat to carbohydrates, synaptosomal NMUR2 protein in the NAc or in the VTA demonstrated opposing results. The article is open access and can found through the link below.
In addition, here are our three most recent Neuromedins:
- A.E. Smith, J.M. Kasper, N.C. Anastasio, and J.D. Hommel, Nutrients, 11(2), 327 (2019). https://doi.org/10.3390/nu11020327