A New Peptides International Publication on the Synthesis of Bestatin
Bestatin, or Ubenimex, is an inhibitor of aminopeptidases, leucine aminopeptidase 3 (LAP3), and a potent, irreversible inhibitor of leukotriene A4 (LTA4) hydrolase.1 Like leupeptin, it was first discovered in culture filtrates of the actinomycetes bacteria.2 As leaders in peptide synthesis, scientists at Peptides International have recently published a new article in the Journal of Peptide Science, entitled, “A Practical Diastereoselective Synthesis of (−)‐Bestatin”. While some synthetic methods of bestatin require expensive chiral catalysts or auxiliaries, we report an 8-step, scalable synthesis starting from Boc-D-Phe-OH.3
You can access the full article here: https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3067
For more on bestatin, click here to take a look at our past product spotlight.
- L. Örning, G. Krivi, & F.A. Fitzpatrick, The Journal of Biological Chemistry, 266,1375 (1991).
- H. Umezawa, et al., Antibiotics, 29(1), 97 (1976).
- S. Shang, A.V. Willems, & S.S. Chauhan, Journal of Peptide Science, 24, e3067 (2018).