Kinase Inhibitors as a Treatment for Viral Infections

Kinase Inhibitors

Antiviral medications are used to treat a narrow range of organisms, and as unbelievable as it sounds, fewer than ten viral infections are treated by currently approved antiviral drugs! And the majority of these are direct-acting antivirals (DAAs) that only target proteins encoded by individual viruses and therefore are able to address only a small range of protection.  

https://www.pepnet.com/res/uploads/media//virus_600px.jpg

A recent review in DNA and Cell Biology summarizes advances and issues that would allow adapting kinase inhibitors as broad-spectrum antiviral therapies, similar to the way antibiotics are currently employed. Taking a cue from anticancer drugs, sunitinib and erlotinib, which have been found to target kinases necessary for every stage of the viral life cycle, the authors suggest repurposing already approved kinase inhibitors as antivirals. There are many advantages to this approach: efficacy and earlier implementation (since specific viral diagnosis would not be needed prior to deployment), a shorter developmental timeline, lower R&D, and therefore lower consumer costs.

The fascinating details are found here:

https://www.genengnews.com/gen-exclusives/repurposing-of-kinase-inhibitors-as-broad-spectrum-antiviral-drugs/77901062

Full-text:

http://online.liebertpub.com/doi/full/10.1089/dna.2017.4033

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Robert Brousseau

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Robert Brousseau, the Director of Marketing and Catalog Sales Development at Peptides International, has a wide range of responsibilities that include maintaining the Peptides International brand integrity and creating and implementing all materials related to marketing the company's product line. He is also tasked with the catalog portfolio sales.  Since joining the company in 2004, he has incorporated media that now includes printed material such as product brochures and the long-running PEPNET newsletter, along with the company Website, social media, email and other outlets.  Additionally, he assists the staff with IT issues they encounter.  Bob has a background in graphic design, marketing, and advertising, in addition to project management and packaging.  He received his B.A. in Art from the University of Louisville, with additional post-graduate studies in education and design.