Inducing Beta Cell Production in Diabetics

Insulin replacement therapy is necessary in type I diabetics and in many type II diabetics. Recently, a team, led by Bruno Doiron at the University of Texas Health Science Center in San Antonio, has been able to transform adult somatic cells into pancreatic beta cells. They take a three-step Cellular Networking, Integration, and Processing (CNIP) approach that does not require stem cells. Their approach integrates glucose metabolism, membrane receptor function, and gene expression, all necessary for in vivo beta cell formation. In their CNIP cocktail, they used lentivirus, taking advantage of its ability to integrate into the genome while not generating an immune response, to express the transcription factors in the cocktail. The cocktail was able to increase plasma insulin levels after treatment as well as decrease blood glucose after treatment. Fortunately, their method induced pancreatic beta cell production without causing injury to the pancreas. The authors believe that their method can be used both as a treatment and a cure.1


  1. B. Doiron, W. Hu, & R. A. DeFronzo, Current Pharmaceutical Biotechnology, 17, 376 (2016). Retrieved from
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Denise Karounos

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Denise Karounos joined Peptides International in October 2016. After completing her BS in chemistry from West Virginia University, she spent time as an organic chemist at Bachem Bioscience synthesizing peptides and amino acid derivatives. Denise has experience with both solid and solution-phase peptide synthesis, and has worked under both research and cGMP settings. After completing her MBA from Saint Joseph’s University, Denise transitioned into product management of peptides and amino acid derivatives. In her marketing role, she had many duties including but not limited to product management, market research, creating and producing marketing materials, handling US catalog distribution and customer database, email marketing, quoting and inside sales, sales calls, and coordinating and attending trade conferences. 

At PI, Denise's duties encompass both sales and marketing, bringing to bear her extensive lab and sales support experience. Contact her today and see how Denise can assist you with your peptide research project.