New and Improved Antimicrobial Peptides!
A team of scientists out of MIT, the University of Brasilia, and the University of British Colombia have engineered a naturally occurring antimicrobial peptide called clavanin-A to increase its effectiveness. They added five hydrophobic amino acids to the N-terminus of the original sequence. Adding the hydrophobic residues will improve its interaction with the cell and its ability to permeate the cell membrane. In its new form, clavanin-MO has the ability to kill E. coli and S. aureus. It has also been found to stifle the inflammatory response that causes sepsis and also has the ability to destroy certain biofilms.2
Another antimicrobial peptide, lugdunin, which we highlight in a recent product spotlight, has been identified from human nasal secretions. Lugdunin is a macrocyclic thiazolidine peptide produced by the bacterium, S. lugdunensis. Lugdunin has been found to kill methicillin-resistant S. aureus (MRSA) and vancomycin-resistant Enterococcus. The researchers hope it can be used as a preventative medicine as well as an antibiotic. 1
- A. Nowogrodski, Nature News, (2016, July 27) Retrieved from http://www.nature.com/news/the-nose-knows-how-to-kill-mrsa-1.20339
- J. Raphael, Nature World News, (2016, Nov 3). Retrieved from http://www.natureworldnews.com/articles/31095/20161103/mit-alters-naturally-occurring-proteins-help-fight-superbugs.htm Full article retrieved from https://dspace.mit.edu/handle/1721.1/105167