Obestatin
Newly Identified Feeding Regulatory Peptides
Obestatin Related Peptides Available from Peptides International

Control of appetite involves a number of gastrointestinal hormones that belong to the ghrelin-motilin ligand family that either stimulate food intake and gastric emptying or inhibit these responses.  These hormones have been the focus of intense research in hopes of developing drug therapy for gastrointestinal and eating disorders. 

Researchers at Stanford University School of Medicine have recently identified a new member of this family by using bioinformatic predictions about enzyme cleavage of the prepropeptide of ghrelin.  The newly identified 23 amino acid, ghrelin-associated peptide was named obestatin (1).    Although both peptides originate from the same precursor prepropeptide, they have opposing physiological roles.  Obestatin exerts anorexigenic effects by decreasing food intake, gastric emptying, jejunal motility, and weight gain by binding to GPR39 orphan receptor, while ghrelin (2) exerts opposing orexigenic effects by binding to growth hormone secretagogue receptor.  Both peptide hormones require post-translational modification for full activity.  For ghrelin, this involves an essential n-octanoylation at the Ser3 position, and it is the first and only peptide hormone identified to have this unique modification to date.  For obestatin, post-translational amidation occurs at the C-terminus. 

Peptides International now offers human and rat obestatin and truncated des (1-10) obestatin analogs, which exhibited lower affinity binding to GPR39 compared to obestatin (1).  Studying the dualistic interaction of these peptides in energy homeostasis may lead to a better understanding of this complex system and may eventually allow the scale to be tipped in the right direction for those who suffer from obesity and other related disorders.  
 

1.  J.V. Zhang, P. Ren, O. Avsian-Kretchmer, C. Luo, R. Rauch, C. Klein, and A.J.W. Hsueh, Science, 310, 996 (2005).
2.  M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa, Nature, 402, 656 (1999).

 

CODE

Obestatin Peptides (PDF)

QTY

USD
PGH-3890-PI Obestatin (Human)
Human, Monkey
H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH2
 FNAPFDVGIKLSGVQYQQHSQAL-NH2
(M.W. 2546.89)  C116H176N32O33
Suppressor of Food Intake and Gastric Emptying

 J.V. Zhang, P. Ren, O. Avsian-Kretchmer, C. Luo, R. Rauch, C. Klein, and A.J.W. Hsueh, Science, 310, 996 (2005).		 1 mg
5 mg		 79
299
 
PGH-3891-PI Obestatin (Rat, Mouse)
H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
 FNAPFDVGIKLSGAQYQQHGRAL-NH2
(M.W. 2516.87)  C114H174N34O31
Suppressor of Food Intake and Gastric Emptying

 J.V. Zhang, P. Ren, O. Avsian-Kretchmer, C. Luo, R. Rauch, C. Klein, and A.J.W. Hsueh, Science, 310, 996 (2005).
 		 1 mg
5 mg		 79
299
 
PGH-3892-PI Des 1-10 Obestatin (Human)
 Obestatin (Human, 11-23)
H-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu- NH2
 H-LSGVQYQQHSQAL-NH2
(M.W. 1457.62)  C63H100N20O20
 Truncated Analog of Obestatin

J.V. Zhang, P. Ren, O. Avsian-Kretchmer, C. Luo, R. Rauch, C. Klein, and A.J.W. Hsueh, Science, 310, 996 (2005).

 1 mg
5 mg		 59
229
PGH-3893-PI Des 1-10 Obestatin (Rat, Mouse)
Obestatin (Rat, Mouse, 11-23)
H-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
 H-LSGAQYQQHGRAL-NH2
 (M.W. 1427.60)  C61H98N22O18
 Truncated Analog of Obestatin
J.V. Zhang, P. Ren, O. Avsian-Kretchmer, C. Luo, R. Rauch, C. Klein, and A.J.W. Hsueh, Science, 310, 996 (2005).		 1 mg
5 mg		 59
229

Please contact Peptides International for ordering information.
Peptides International, Inc.
PO Box 24658
Louisville, Kentucky 40224 USA
Phone: 502-266-8787 or 800-777-4779
Fax: 502-267-1FAX (1329)
Email:  peptides@pepnet.com

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