Defensins, Magainin, and Liver-Expressed Antimicrobial Peptides
Available from Peptides International

Numerous articles in the scientific journals and the popular press warn of the growing examples of resistance to antibacterial drugs. Many organisms have developed their own defenses based on peptides, such as defensins, magainins and cecropins.  Defensin peptides are effective against a wide spectrum of microbes including bacteria, viruses, fungi, spirochetes and mycobacteria.  Human b-Defensin-1 (hBD1), originally isolated from hemofiltrate, is a cationic, Cys-rich antimicrobial peptide and is specific for Gram negative bacteria such as E. coli and Pseudomonas aeruginosa, the same as human b-defensin-2 (hBD2). This peptide is found in the epithelia of the urogenital tract, lung and trachea and could be a valuable tool, along with the other defensins, for probing self-defense mechanisms.

To date, six human alpha-defensins are classified into two sub-groups, the human neutrophil peptides (HNP) (HNP-1 to HNP-4) and the human defensins (HD), HD-5 and HD-6, which are antimicrobial peptides predominantly expressed in Paneth cells of the ileum.  In addition to alpha-defensin-1 (HNP-1) (PDF- 4271-s), two new alpha-defensin peptides, alpha-defensin-3 (HNP-3) (PDF-4416-s) and alpha-defensin-5 (HD-5) (PDF-4415-s), are now available from the Peptide Institute and Peptides International to facilitate research efforts.  In recent years, additional defensin peptides, hBD3 and hBD4, as well as the Liver-Expressed Antimicrobial Peptides 1 and 2, were also made available to the antimicrobial research community as high purity, synthetic research tools.  

For further information about our antimicrobial products, please contact our technical specialists today.
 
Defensin Review Articles
R.I. Lehrer and T. Ganz, Ann. N.Y. Acad. Sci., 797, 282 (1996). (Review)
M. Zasloff, Nature, 415, 389 (2002). (Review) here
New Peptides

CODE

PRODUCT DESCRIPTION

QTY

USD
Defensin Peptides and Beta-Defensin-2 Antisera

PDF-4271-s

 a-Defensin-1 (Human)
Alpha-Defensin-1 (Human)
HNP-1 (Human Neutrophil Peptide-1)
Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys
(Disulfide bonds: Cys2-Cys30, Cys4-Cys19 and Cys9-Cys29)
M.W. 3442.1 C150H222N44O38S6
Antimicrobial Peptide / Chemoattractant for Monocyte
T. Ganz et al. J. Clin. Invest., 76, 1427 (1985).
M.E. Selsted et al. J. Clin. Invest., 76, 1436 (1985). (Original; Isolation)

0.1 mg vial

212

PDF-4416-s
NEW!

a-Defensin-3 (Human)
Alpha-Defensin-3 (Human)
 HNP-3 (Human Neutrophil Peptide-3)
Asp-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys
(Disulfide bonds between Cys2-Cys30, Cys4-Cys19, and Cys9-Cys29)
 (M.W. 3486.0) C151H222N44O40S6
 Antimicrobial Peptide
T. Ganz, M.E. Selsted, D. Szklarek, S.S.L. Harwig, K. Daher, D.F. Bainton, and R.I. Lehrer, J. Clin. Invest., 76, 1427 (1985). (Original; Isolation)
 M.E. Selsted, S.S.L. Harwig, T. Ganz, J.W. Schilling, and R.I. Lehrer, J. Clin. Invest., 76, 1436 (1985). (Original; Structure)
 L. Zhang, W. Yu, T. He, J. Yu, R.E. Caffrey, E.A. Dalmasso, S. Fu, T. Pham, J. Mei, J.J. Ho, W. Zhang, P. Lopez, and D.D. Ho, Science, 298, 995 (2002).  (Pharmacol.; Anti-HIV-1 Activity)

0.1 mg vial

212

PDF-4415-s
NEW!

a-Defensin-5 (Human)
Alpha-Defensin-5 (Human)
 Human Defensin-5 (HD-5)
 Ala-Thr-Cys-Tyr-Cys-Arg-Thr-Gly-Arg-Cys-Ala-Thr-Arg-Glu-Ser-Leu-Ser-Gly-Val-Cys-Glu-Ile-Ser-Gly-Arg-Leu-Tyr-Arg-Leu-Cys-Cys-Arg
(Disulfide bonds between Cys3-Cys31, Cys5-Cys20, and Cys10-Cys30)
(M.W. 3582.1) C144H238N50O45S6
Antimicrobial Peptide in Paneth Cells

D.E. Jones and C.L. Bevins, J. Biol. Chem., 267, 23216 (1992).  (Original)
 E. Martin Porter, M.A. Poles, J.S. Lee, J. Naitoh, C.L. Bevins, amd T. Ganz, FEBS Lett., 434, 272 (1998).  (Endogenous Form)
 N.H. Salzman, D. Ghosh, K.M. Huttner, Y. Paterson, and C.L. Bevins, Nature, 422, 522 (2003).  (Pharmacol.)

 0.1 mg vial

232

PDF-4337-s

 b-Defensin-1 (Human)
Beta-Defensin-1 (Human)
hBD-1
Asp-His-Tyr-Asn-Cys-Val-Ser-Ser-Gly-Gly-Gln-Cys-Leu-Tyr-Ser-Ala-Cys-Pro-Ile-Phe-Thr-Lys-Ile-Gln-Gly-Thr-Cys-Tyr-Arg-Gly-Lys-Ala-Lys-Cys-Cys-Lys
(Disulfide bonds between Cys5-Cys34, Cys12-Cys27, and
Cys17-Cys35)
(M.W. 3928.6) C167H256N48O50S6
Antibacterial Peptide
K.W. Bensch, M. Raida, H-J. Mägert, P. Schulz-Knappe, and W.-G. Forssmann, FEBS Lett., 368, 331 (1995). (Original)
M.J. Goldman, G.M. Anderson, E.D. Stolzenberg, U.P. Kari, M. Zasloff, and J.M. Wilson, Cell, 88, 553 (1997). (Pharmacol.; Inactivated in Cystic Fibrosis)
 T. Hiratsuka, M. Nakazato, T. Ihi, T. Minematsu, N. Chino, T. Nakanishi, A. Shimizu, K. Kangawa, and S. Matsukura, Nephron, 85, 34 (2000). (Pharmacol.)		 0.1 mg vial

229

PDF-4338-s

 b-Defensin-2 (Human)
Beta-Defensin-2 (Human)
hBD-2
Gly-Ile-Gly-Asp-Pro-Val-Thr-Cys-Leu-Lys-Ser-Gly-Ala-
Ile-Cys-His-Pro-Val-Phe-Cys-Pro-Arg-Arg-Tyr-Lys-
Gln-Ile-Gly-Thr-Cys-Gly-Leu-Pro-Gly-Thr-Lys-Cys-
Cys-Lys-Lys-Pro
 (Disulfide bonds between Cys8-Cys37, Cys15-Cys30, and Cys20-Cys38)
(M.W. 4328.2) C188H305N55O50S6
Antibacterial Peptide Specific for Gram-Negative Bacteria / Also Effective for Candida albicans
J. Harder, J. Bartels, E. Christophers, and J.-M. Schröder, Nature, 387,
861 (1997). (Original)
T. Hiratsuka, M. Nakazato, Y. Date, J. Ashitani, T. Minematsu, N. Chino, and S. Matsukura, Biochem. Biophys. Res. Commun., 249, 943
(1998). (Pharmacol.)
D.M. Hoover, K.R. stophers, and J.-M. Schröder, J. biol. Chem., 275, 32911 (2000), (S-S Bond)
T. Hiratsuka, H. Mukae, H. Iiboshi, J. Ashitani, K. Nabeshima, T. Minematsu, N. Chino, T. Ihi, S. Kohno, and M. Nakazato, Thorax, 58, 425 (2003). (Pharmacol.; Activity against Pseudomonas aeruginosa)		 0.1 mg vial

247

NBD-14338-v

 b-Defensin-2 (Human) Antiserum (Rabbit)
Antiserum: lyophilized from 0.001 M phosphate buffer (pH 7.0)
Immunogen: b-Defensin-2 (Human)-TG (TG: Bovine Thyroglobulin)
Reactivity: b-Defensin-2 (Human) +
b-Defensin-1 (Human) -
a-Defensin-2 (Human) -

50 mL vial

339

PDF-4382-s
 

 b-Defensin-3 (Human)
Beta-Defensin-3 (Human)
hBD-3
Gly-Ile-Ile-Asn-Thr-Leu-Gln-Lys-Tyr-Tyr-Cys-Arg-Val-Arg-Gly-Gly-Arg-Cys-Ala-Val-Leu-Ser-Cys-Leu-Pro-Lys-Glu-Glu-Gln-Ile-Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys
(Disulfide bonds between Cys11-Cys40, Cys18-Cys33, and Cys23-Cys41)
(M.W. 5155.1) C216H371N75O59S6
Antimicrobial Peptide / Staphylococcus aureus-Killing Factor

J. Harder, J. Bartels, E. Christophers, and J.-M. Schröder, J. Biol. Chem., 276, 5707 (2001). (Original)
J.-R.C. García, F. Jaumann, S. Schulz, A. Krause, J. Rodrínguez-Jiménez, U. Forssmann, K. Adermann, E. Klüver, C. Vogelmeier, D. Becker, R. Hedrich, W.-G. Forssmann, and R. Bals, Cell Tissue Res., 306, 257 (2001). (Original; Amino-Terminally Truncated Peptide)
L.A. Duits, M. Rademaker, B. Ravensbergen, M.A.J.A. van Sterkenburg, E. van Strijen, P.S. Hiemstra, and P.H. Nibbering, Biochem. Biophys. Res. Commun., 280, 522 (2001). (Pharmacol.)
H.P. Jia, B.C. Schutte, A. Schudy, R. Linzmeier, J.M. Guthmiller, G.K. Johnson, B.F. Tack, J.P. Mitros, A. Rosenthal, T. Ganz, and P.B. McCray, Jr., Gene, 263, 211 (2001). (DNA Seq/Tissue Distribution)
D.J. Schibli, H.N. Hunter, V. Aseyev, T.D. Starner, J.M. Wiencek, P.B. McCray, Jr., B.F. Tack, and H.J. Vogel, J. Biol. Chem., 277 8279 (2002). (Solution Structure)

0.1 mg vial

255

PDF-4406-s
NEW!

 b-Defensin-4 (Human)
Beta-Defensin-4 (Human)
hBD-4
Prepro hBD-4 (Human, 25-61)
Glu-Leu-Asp-Arg-Ile-Cys-Gly-Tyr-Gly-Thr-Ala-Arg-Cys-Arg-Lys-Lys-Cys-Arg-Ser-Gln-Glu-Tyr-Arg-Ile-Gly-Arg-Cys-Pro-Asn-Thr-Tyr-Ala-Cys-Cys-Leu-Arg-Lys
(Disulfide bonds between Cys6-Cys33, Cys13-Cys27,
and Cys17-Cys34)
(M.W. 4366.0) C180H295N63O52S6
Antimicrobial Peptide / Chemoattractant for Monocytes

B.C. Schutte, J.P. Mitros, J.A. Bartlett, J.D. Walters, H. Peng Jia, M.J. Welsh, T.L. Casavant, and P.B. McCray, Jr., Proc. Natl. Acad. Sci., U.S.A., 99, 2129 (2002). (b -Defensin Family Peptides)
J.-R.C. García, A. Krause, S. Schulz, F.-J. Rodríguez-Jiménez, E. Klüver, K. Adermann, U. Forssmann, A. Frimpong-Boateng, R. Bals, and W.-G. Forssmann, FASEB J., 15, 1819 (2001). (Original; hBD-4 & S-S Bond)

0.1 mg vial

229
NEW! Liver-Expressed Antimicrobial Peptides

PLP-4392-s
 

 Liver-Expressed Antimicrobial Peptide 1 (Human)
LEAP-1/Hepcidin (Human)
LEAP Page
Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-
Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr
(Disulfide bonds between Cys7-Cys13, Cys10-Cys23,
Cys11-Cys22, and Cys14-Cys19)
(M.W. 2789.4) C113H170N34O31S9
Liver-Specific Antimicrobial Peptide / Iron-Regulatory Hormone
M. Zasloff, Nature, 475, 389 (2002). (Review)
A. Krause, S. Neitz, H.-J. Mägert, A. Schulz, W.-G. Forssmann, P. Schulz-Knappe, and K. Adermann, FEBS Lett., 480, 147 (2000). (Original; LEAP-1)
C.H. Park, E.V. Valore, A.J. Waring, and T. Ganz, J. Biol. Chem., 276, 7806 (2001). (Original; Hepcidin/Proposed Disulfide Bond Connectivity)
H.N. Hunter, D.B. Fulton, T. Ganz, and H.J. Vogel, J. Biol. Chem., 277, 37597 (2002). (S-S Bond)
R.E. Fleming and W.S. Sly, Proc. Natl. Acad. Sci. U.S.A., 98, 8160 (2001). (Regulation of Iron Homeostasis)

0.1 mg vial

195

PLP-4405-s
NEW!

 Liver-Expressed Antimicrobial Peptide 2 (Human)
LEAP-2 (Human)
LEAP Page
Prepro LEAP-2 (Human, 38-77)
Met-Thr-Pro-Phe-Trp-Arg-Gly-Val-Ser-Leu-Arg-Pro-Ile-Gly-
Ala-Ser-Cys-Arg-Asp-Asp-Ser-Glu-Cys-Ile-Thr-Arg-Leu-
Cys-Arg-Lys-Arg-Arg-Cys-Ser-Leu-Ser-Val-Ala-Gln-Glu
(Disulfide bonds between Cys17-Cys28 and Cys23-Cys33)
(M.W. 4581.3) C191H316N64O57S5
Antimicrobial Peptide
A. Krause, R. Sillard, B. Kleemeier, E. Klüver, E. Maronde, J.R. Conejo-García, W.G. Forssmann, P. Schulz-Knappe, M.C. Nehls, F. Wattler, S. Wattler, and K. Adermann, Protein Sci., 12, 143 (2003). (Original & S-S Bond)

0.1 mg vial

229
Related Antibacterial Peptides

PMG-4196-v

 Magainin 1
Potent Antimicrobial Peptide
M. Zasloff, Proc. Natl. Acad. Sci. USA, 84, 5449 (1987).		 0.5 mg vial

269
Please contact our technical sales specialists to discuss your project needs.

Please contact Peptides International for ordering information.
Peptides International, Inc.
PO Box 24658
Louisville, Kentucky 40224 USA
Phone: 502-266-8787 or 800-777-4779
Fax: 502-267-1FAX (1329)
Email:  peptides@pepnet.com

HOME  | Back to Products |   E-mail

Search Main Menu Email

Peptides International