Calpain Inhibitors and
Substrates |
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CALPAIN INHIBITORS: ALLN
AND ALLM Calpain, a calcium-activated cysteine protease present in most mammalian tissues, is a potential therapeutic target for neurodegeneration prevention. Calpain has been implicated in neural cell death associated with cerebral ischemia, neurodegenerative processes such as Alzheimer's disease, myocardial ischemia, and cataract formation.1 Ac-Leu-Leu-Nle-H and Ac-Leu-Leu-Met-H aldehydes are non-specific cysteinyl protease inhibitors.2 These cell-permeable aldehydes are most effective against the chymotrypsin-like proteolytic activity of the proteasomes. Both ALLN and ALLM should be useful for calpain function studies since this remains poorly understood. |
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1. R.L. Debiasi, M.K.T. Squier, B. Pike, M. Wynes, T.S. Dermody, J.J. Cohen, and K.L. Tyler, J. Virology, 73, 695 (1999). 2. T. Sasaki, M. Kishi, M. Saito, T. Tanaka, N. Higuchi, E. Kominami, N. Katunuma, and T. Murachi, J. Enzyme Inhib., 3, 195 (1990). |
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CODE |
DESCRIPTION |
VIAL |
USD |
| Calpain Inhibitors | |||
| IAL-3671-PI |
Ac-Leu-Leu-Nle-H (aldehyde) Synthetic Product ALLN, MG 101 Acetyl-L-Leucyl-L-Leucyl-L-Norleucinal (M.W. 383.54) C20H37N3O4 Inhibitor for Calpain I and Proteasome |
5 mg |
46 |
| IAL-3678-PI |
Ac-Leu-Leu-Met-H
(aldehyde) |
5 mg |
46 |
| Calpain Substrates | |||
MVL-3104-v |
Boc-Val-Leu-Lys-MCA
Substrate for Plasmin and Calpain |
5 mg vial |
63 |
MLL-3120-v |
Suc-Leu-Leu-Val-Tyr-MCA Substrate for Chymotrypsin, Ingensin / Proteasome, and Calpain |
5 mg vial |
70 |
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Please note: Carbobenzoxy (Cbz) = Benzyloxycarbonyl
(Z) protecting group in peptide chemistry |
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Please contact Peptides International for ordering
information. |
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