New Angiotensin-Converting Enzyme-Related
Carboxypeptidase (ACE2) Fluorogenic Substrates
New substrates now available from Peptides International

ACE2 is highly expressed in heart, kidney, and testis and is found in low levels in the colon, small intestines, and ovary.ACE2 cleaves angiotensin I and II, des-Arg-Bradykinin, neurotension 1-13, kinetensin, apelin 13, and dynorphin 1-13 but not bradykinin and other typical vasoactive peptides. Yet, its activity is not blocked by common inhibitors such as captopril. These points seem to suggest ACE2 plays role in renin-angiotensin. Due to the significance to cardiovascular research, Yan and coworkers developed selective fluorogenic substrates to aid in the quest for potent inhibitors for this enzyme. These recently reported optimal substrates should aid high throughput screening efforts to identify ACE2 inhibitors.

Z.-H. Yan, K.-J. Ren, Y. Wang, S. Chen, T.A. Brock, and A. Rege, Anal. Biochem., 312, 141-147 (2003).

(taken from Z.-H. Yan, et al.)

Abz-Gly-Phe-Ser-Pro-Tyr(NO₂)-OH
Kinetic measurements with ACE2 Km=58 mM and k_cat/K_m= 1.3 x 10⁵ M^-1s^-1

Abz-Ser-Pro-Tyr(NO₂)-OH (more selective for ACE2)
Kinetic measurements with ACE2 Km=23 mM and k_cat/K_m=3.5 x 10⁴ M^-1s^-1

CODE

PRODUCT DESCRIPTION

QTY

USD

SFQ-3817-PI
NEW!

1 mg
5 mg

45
160

SFQ-3819-PI
NEW!

1 mg
5 mg

45
160

ACE2: angiotensin-converting enzyme-related carboxypeptidase

Please contact Peptides International for ordering information.
Peptides International, Inc.
PO Box 24658
Louisville, Kentucky 40224 USA
Phone: 502-266-8787 or 800-777-4779
Fax: 502-267-1FAX (1329)
Email:  peptides@pepnet.com

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